The South Africans beat the English 29-20 at in London last weekend and they will now aim to complete their three-game Autumn Nations Series unbeaten with a team showing two backline alterations and five more switches in the pack against the Welsh.
South Africa maintained their status as the number one side in the world with a 20-29 victory over England at Twickenham's Allianz Stadium on Saturday.
South Africa were 32-15 winners in Edinburgh in their Autumn Nations Series opener and they have now altered all seven of their starting backs, five of their starting forwards and pared their bench from a seven-one forwards/backs split back to a five/three divide.
It is a strange scenario where a defeated coach hails a 17-point loss as “one of their best performances” in recent times and the victorious coach claims he is “not very proud” of a victory where his side prevented dangerous opponents from scoring a try.
The Springboks have become back-to-back Rugby World Cup champions, while the former winger is now thriving in his transition from retiring as a player to forging a new career in business and rugby punditry.
South Africa's phenomenal depth and conveyor belt of muscular titans makes this a question worth asking.
The back-to-back Rugby World Cup champions had already lost Jan-Hendrik Wessels and Damian Willemse for the November tour to Scotland, England and Wales, replacing them with Johan Grobbelaar and Cameron Hanekom.
.Munster suffered a third successive defeat in the United Rugby Championship after losing 41-24 to Sharks in Durban.