Johann van Graan has selected a completely different pack to the one that started the 61-26 thrashing of Gloucester in last Sunday's Challenge Cup quarter-final for this weekend's trip to Exeter.
Scotland playmaker Finn Russell will be hoping to show the sort of form that helped beat Challenge Cup quarter-final opponents Gloucester in the Premiership last month.
England lock Ollie Chessum will return to Leicester Tigers' starting XV on Sunday as his side host Saracens in the Gallagher Premiership.
England captain Maro Itoje will return to captain a Saracens side containing four of his international team-mates during the Guinness Six Nations when they host Harlequins in the Gallagher Premiership on Saturday.
Matt Currie has been called into the Scotland squad just days after scoring a hat-trick for Edinburgh against Munster in the United Rugby Championship.
Gregor Townsend has called Ross McCann, Ali Price and Cameron Redpath into his Scotland squad that are in Spain currently preparing to take England on at Twickenham's Allianz Stadium this Saturday in round three of the Guinness Six Nations.
There was intrigue in a call-up for the latest ‘kilted Kiwi’ Fergus Burke and a ‘bolter’ in Glasgow No.8 Jack Mann.
Mark McCall believes it is all about how Saracens respond after the six-time champions suffered a record Gallagher Premiership defeat.