England captain Maro Itoje will return to captain a Saracens side containing four of his international team-mates during the Guinness Six Nations when they host Harlequins in the Gallagher Premiership on Saturday.
The Gallagher Premiership leaders remain on course for the treble after a 48-14 victory over Exeter at Sandy Park.
Wales have been boosted by the return of Dewi Lake to the squad ahead of their Guinness Six Nations trip to Scotland.
Matt Sherratt has wasted little time in putting his stamp on the Wales squad for the remainder of the Six Nations, calling up three players and sidelining coach Rob Howley.
Wales head coach Warren Gatland has called up Ospreys prop Ben Warren into his Guinness Six Nations squad.
Warren Gatland is shy of quality in some areas but the Wales coach's Six Nations picks must deliver if he is to keep his job.
The uncapped duo of Ospreys fly-half Dan Edwards and Scarlets wing Ellis Mee have been selected by Warren Gatland for Wales' Guinness Six Nations campaign.
Wales international Dafydd Jenkins is fit and available for selection and could make his seasonal bow for Exeter at home to Toulouse in the second round of the Investec Champions Cup on Sunday.