Ben Waghorn was a starter in the World Rugby U20 Championship final last July in Cape Town with Lucas Friday appearing off the bench against the French.
Beaten last weekend away to champions Northampton, Quins have included full-back Leigh Halfpenny for Jarrod Evans, wing Caden Murley for Will Joseph and scrum-half Will Porter for the benched Danny Care in their backs.
Statistically, Quins had the most successful scrum in the Premiership last season, anchored by tighthead Will Collier, while Springbok centre Esterhuizen ate up the post-contact metres to turn defences on their heels and enable half-backs Danny Care and Marcus Smith to work their magic.
Experienced tighthead has “never retired from Test rugby” but says his current focus is on his family and contract in France.
Wales are aiming to bounce back from their Sydney defeat in the second Test.
Wales' Rob Howley has been unable to confirm whether Aaron Wainwright, Liam Williams and four others will be available to take on the Wallabies.
Wales have lost their last 11 Tests against the Wallabies in Australia.
Wales head out to Australia this week for a tour which takes in two Tests against the Wallabies and a meeting with the Queensland Reds.