Italy and Argentina have both named sides with only two players with fewer than 10 caps for their encounter in Udine on Saturday.
Zebre Parma made history by securing their first-ever victory over Munster with a 42-33 bonus-point win in the United Rugby Championship.
Italy head coach Gonzalo Quesada has announced a preliminary squad of 39 players for a training camp in L'Aquila from 19 to 22 June, in preparation for the 2024 summer tour.
Scotland fly-half Adam Hastings has returned to the Gloucester squad to face Benetton on Saturday in the Challenge Cup semi-final at Kingsholm after missing the loss to Exeter Chiefs last week in the Gallagher Premiership.
Italy have made three changes from the team that defeated Scotland last weekend for their Wooden Spoon decider against Wales at the Principality Stadium on Saturday in round five of the Guinness Six Nations.
The first Guinness Six Nations after a World Cup often sees a changing of the guard, with new faces emerging as a fresh four-year cycle begins.
Zebre Parma claimed a converted try five minutes into stoppage time to salvage a 22-22 draw against United Rugby Championship opponents Cardiff in northern Italy.
Zebre Parma have lost 28 games in a row. How do they handle the constant anguish?
Italy's revamped youth pathway should make the next four years wonderful for the Azzurri, says the man who made it happen.