Italy and Argentina have both named sides with only two players with fewer than 10 caps for their encounter in Udine on Saturday.
In just a few days another season of the Top 14 kicks off with the likes of Owen Farrell, Siya Kolisi, Josua Tuisova, and Davit Niniashvili making the numbers of the overseas players ready to make the headlines and wrestle for the title.
Italy head coach Gonzalo Quesada has announced a preliminary squad of 39 players for a training camp in L'Aquila from 19 to 22 June, in preparation for the 2024 summer tour.
Scotland fly-half Adam Hastings has returned to the Gloucester squad to face Benetton on Saturday in the Challenge Cup semi-final at Kingsholm after missing the loss to Exeter Chiefs last week in the Gallagher Premiership.
Leinster's signing of Jordie Barrett from the Hurricanes is maybe the standout move in this season's flurry of rugby transfers.
Montpellier Herault second-row Paul Willemse has received a suspension after an independent Disciplinary Hearing related to his actions in the EPCR Challenge Cup, Round of 16 match against Ulster Rugby at GGL Stadium last weekend.
Italy have made three changes from the team that defeated Scotland last weekend for their Wooden Spoon decider against Wales at the Principality Stadium on Saturday in round five of the Guinness Six Nations.
Harlequins winger Louis Lynagh is set to make his Italy debut on Saturday in round four of the Guinness Six Nations as head coach Gonzalo Quesada has made three changes from the XV that drew with France in round three.