The hosts enjoyed an 18-point lead at half-time after tries from Morne van den Berg, Henco van Wyk, and Marius Louw.
Munster returned to winning ways in the United Rugby Championship a month on from Graham Rowntree’s departure with a 17-10 victory.
.Leinster made it six wins in a row in the United Rugby Championship this season with a dogged 24-6 triumph over Lions at the Aviva Stadium.
The Lions' unbeaten start to the season came to an abrupt end this afternoon as they fell 24 - 6 to Leinster at the Aviva Stadium.
Leinster player ratings: Leinster delivered an impressive performance in front of the 18,000 or so fans packed in the Aviva, showcasing flashes of brilliance in attack while keeping the Lions’ threats at bay for most of the game.
Ulster fell to a 35-22 loss to Lions in Johannesburg but could take some encouragement from a point on the road in the United Rugby Championship.
Despite the Lions having lock Ruben Schoeman red-carded after 26 minutes, they claimed a bonus-point victory.
The four-year cycle leading up to the World Cup in Australia has started and Lions head coach Ivan van Rooyen believes he has players that can play a big role for the Springboks.