Argentina winger Emiliano Boffelli will make his first appearance of the season for Edinburgh when they host Lions on Friday night.
The Lions picked up their first win since the opening round of the United Rugby Championship as they triumphed 37-19 over the Stormers in Cape Town.
The match will see the return to action of Jaco Kriel, who left Premiership side Gloucester at the start of the year to return to SA and the Lions earlier this year.
EW Viljoen went to Leicester hoping to make a lasting Premiership impression but the new Lions signing made just four appearances in a truncated season.
The Bulls recorded their first win of the season when they smashed the Highlanders 38-13 in Pretoria on Saturday.
Both the Stormers and the Bulls have kept changes to a minimum ahead of their massive South African derby in Cape Town this weekend.
Follow all the action on the RugbyPass live blog from the Super Rugby match between the Sharks and the Bulls at Jonsson Kings Park.
Head coaches Sean Everitt and Pote Human have named their sides for this weekend's Super Rugby clash between the Sharks and the Bulls in Durban on Friday.
Super Rugby has been somewhat underwhelming to date – which is why it’s so exciting to finally be in the knockout rounds. The cream has risen to the crop and we're now set for some fascinating clashes between Super Rugby's top sides.