The Cherry and Whites were blown away by 14 tries at Franklin’s Gardens, the 0-90 loss igniting massive criticism about the coach.
Leaders Northampton secured a home semi-final in the Gallagher Premiership with a 90-0 annihilation of an under-strength Gloucester, their record win in the competition.
Tom Parton scored the earliest hat-trick in Gallagher Premiership history as Saracens eased to a 46-24 victory over a much-changed Gloucester at the StoneX Stadium.
Gloucester fly-half Adam Hastings is set to make his return from injury on Friday against the Ospreys in the Challenge Cup quarter-final at Kingsholm.
Arron Reed’s first-half double earned Sale a hard-fought 24-10 Gallagher Premiership victory over Gloucester.
England fly-half George Ford is set to start for Sale Sharks on Friday against Gloucester one week after facing Argentina in the World Cup bronze final at the Stade de France.
Gloucester director of rugby George Skivington played down the significance of a first Gallagher Premiership away victory in nearly a year after his side edged to an 18-14 win over Newcastle Falcons.
Gloucester back-rower Jake Polledri will play for his first match in nearly two years when he lines out for his club in Wednesday’s Premiership Rugby Cup fixture versus Worcester at Kingsholm.