There are seven changes to the starting XV, including two new caps in the pack, while there is also a first start for Sam Prendergast.
The veteran trio has a combined age of 107 yet Andy Farrell wants his on-field ambassadors to stick around.
The 30-year-old, who won his 10th cap when he started Scotland’s final summer tour Test against Uruguay, had just recovered from a quad issue sustained in pre-season which ruled him out of Edinburgh’s first four United Rugby Championship matches.
The former Ireland backrow hopes to use his experience to help guide the next generation and learn from his mistakes
Who are the rising stars and fresh faces to keep an eye on throughout the coming months?
The precocious back and eldest of five siblings shone on his introduction to the Test arena in South Africa.
The Glasgow and Scotland prop is finally on the comeback trail after some dark times over the past 17 months.
Former Ireland full-back Geordan Murphy, the ex-Leicester director of rugby, popped his head back above the parapet in November when he helped to coach the Barbarians team that took on Northampton in a Franklin’s Gardens exhibition match.