John Mitchell makes seven changes to the starting team who beat the Black Ferns 24-12 at Allianz Stadium as the Red Roses begin their WXV 1 defence against the USA on 29 September.
21 players who were involved in England’s successful campaign in the inaugural WXV 1 tournament return for a second year.
Sarah McKenna has received her first England call-up under John Mitchell as part of a training squad that contains eight uncapped players.
Exeter Chiefs flanker Maddie Feaunati and Trailfinders Women prop Liz Crake have both earned full-time England contracts for the 2024-25 season.
The English, who are chasing a sixth successive championship title but a first with their Kiwi coach in charge, turned on the style last Saturday to blitz Ireland 88-10 in front of a near-50,000 attendance at Twickenham.
Looking to win their sixth successive championship title, the English came away from Edinburgh last weekend with a 46-0 round three win over Scotland.
Amy Cokayne will pull on an England jersey for the first time in more than a year when the Red Roses take on Scotland at a sold-out Hive Stadium on Saturday.
The defending champions eventually put Italy to the round one sword last Sunday in Parma, winning 48-0 despite the loss of Sarah Beckett to an early red card.
England captain Marlie Packer will make her 100th appearance for the Red Roses in the opening round of the 2024 Women’s Six Nations when England play Italy in Parma.