Wales legend Leigh Halfpenny will make his Harlequins debut on Saturday against London Scottish at the Stoop in a pre-season friendly.
Harlequins have been forced into a late change with England prop Joe Marler being withdrawn from the matchday team.
England and British and Irish Lions fly-half Marcus Smith will make his first start for Harlequins after missing last week's Gallagher Premiership Round 2 loss to Saracens.
England skipper Owen Farrell will captain Saracens this Saturday at The Stoop but he won’t face Test teammate Marcus Smith as Harlequins have continued with his pre-season rest programme for the round two Gallagher Premiership match.
Harlequins have confirmed a 68-man senior squad - consisting of 43 senior players and bolstered by 25 from the club’s senior academy - for the upcoming 2022/23 season.
Saracens have made 13 changes to their XV for this Saturday’s Gallagher Premiership semi-final at home to defending champions Harlequins, who have changed just two of their for the playoff fixture. Mark MacCall’s team were hammered 54-7 last Saturday.