Argentina booked their place in the World Cup semi-finals next week with a hard-fought 29-17 over Wales in Marseille on Saturday.
Italy, who wasted a host of chances, now look destined to finish bottom of the Six Nations table.
Lyon attack coach Kendrick Lynn on the injury crisis at the club ahead of the weekend's Champions Cup match against undefeated Leinster in Dublin
Thomas Francis, Aaron Wainwright, George North and Leigh Halfpenny are fresh injuries to go alongside the myriad casualties that the Welsh have had to contend with in Japan.
In a bizarre reversal of Sam Warburton's 2011 red card against France, it was a split-second act that will haunt Vahaamahina for the rest of his career.
France's campaign in Japan has taken on a divisive dynamic similar to previous World Cups, but it appears a truce has been found to ease strained relationships in time for the quarter-finals.
The 2019 World Cup was supposed to be a fitting end to Wesley Fofana's Test level career, but injury has prematurely forced him out of Jacques Brunel's French squad.
It's been 12 years since Argentina turned the rugby world on its head to upset France 17-12 in their own backyard in the 2007 World Cup opener.
RugbyPass hears how France's poor performances in the 2019 Six Nations have failed to help move the sport on locally from the bleakness of three tragic player deaths last year.
France have made four changes to the side that were thrashed 44-8 by England for their upcoming Guinness Six Nations match with Scotland.