Italy and Argentina have both named sides with only two players with fewer than 10 caps for their encounter in Udine on Saturday.
Former Bath and England U20 fullback Matt Gallagher is in line to make his Italy debut this Friday against Samoa after being selected to start by head coach Gonzalo Quesada.
Italy head coach Gonzalo Quesada has announced a preliminary squad of 39 players for a training camp in L'Aquila from 19 to 22 June, in preparation for the 2024 summer tour.
Scotland fly-half Adam Hastings has returned to the Gloucester squad to face Benetton on Saturday in the Challenge Cup semi-final at Kingsholm after missing the loss to Exeter Chiefs last week in the Gallagher Premiership.
Italy have made three changes from the team that defeated Scotland last weekend for their Wooden Spoon decider against Wales at the Principality Stadium on Saturday in round five of the Guinness Six Nations.
Harlequins winger Louis Lynagh is set to make his Italy debut on Saturday in round four of the Guinness Six Nations as head coach Gonzalo Quesada has made three changes from the XV that drew with France in round three.
Italy head coach Gonzalo Quesada has named his 34-player squad that will prepare to take on Scotland and Wales in the final two rounds of the Guinness Six Nations, with back rows Sebastian Negri and Lorenzo Cannone returning after picking up injuries in round one against England.
Harlequins' departing winger Louis Lynagh has been called into Gonzalo Quesada's Italy squad this week as they prepare to face France in Lille in round three of the Guinness Six Nations.
Italy player ratings: Ireland may have made six changes but if you turn up in Dublin without your two best ball carriers and with replacements who lack the same impact then an upset is not on the cards.
Luca Sperandio and Niccolo Cannone scored two tries apiece as Benetton Treviso stretched their unbeaten run to eight games.