The South African visitors were without a number of Rugby World Cup-winning Springboks, including Siya Kolisi, Eben Etzebeth and Bongi Mbonambi, and Leicester tore them apart.
United Rugby Championship leaders Leinster made it seven wins from seven as a late try from James Culhane allowed them to defeat Ulster 27-20.
Versatile Leinster back Osborne and Ulster wing Stockdale sustained groin and hamstring issues respectively during Saturday’s 52-17 win over Fiji.
The final full weekend of the Autumn Nations Series 2024 gets underway on Friday with the majority of teams looking to end the year on a high.
Andy Farrell saw his men put in one of their worst performances under his tenure and that has made a win over Los Pumas pivotal
Ulster head coach Richie Murphy has named his team for the BKT United Rugby Championship Round 6 match against Cardiff on Saturday - with no sign of hooker Rob Herring in the squad.
Caelan Doris has been named Ireland captain for the Autumn Nations Series, taking over from Peter O'Mahony who has also been named in the squad.
Ulster returned to winning ways with a hard-fought 32-27 United Rugby Championship victory over Connacht at Kingspan Stadium.
Giants of Irish rugby must go to the well again as a monumental Test series against the Springboks looms.