The Irish province opened their latest Investec Champions Cup campaign with a 33-7, bonus point win over Stade Francais in Limerick last Saturday.
There are seven changes to the starting XV, including two new caps in the pack, while there is also a first start for Sam Prendergast.
Robbie Henshaw has been named at inside centre at the expense of Bundee Aki. At the same time, uncapped duo Thomas Clarkson and Sam Prendergast join Ryan Baird and Craig Casey among the replacements.
A perennial problem for Irish rugby is once again rearing its ugly head.
Munster player ratings: Munster lost 26 - 12 to rivals Leinster in front of a league record 80,000-plus fans at the iconic Croke Park stadium in Dublin.
Leo Cullen’s unbeaten URC table-toppers defeated Benetton 35-5 last weekend in Italy and they have altered their line-up with two changes in the pack and one in the backs.
The veteran back-rower and tighthead Oli Jager were starters in last Saturday’s rain-sodden win over Ospreys.
Munster returned to winning ways at a rain-lashed Virgin Media Park by beating Ospreys 23-0 in a repeat of last season’s BKT United Rugby Championship quarter-finals.
Munster legend Donncha O'Callaghan has blasted his former team following their shock to defeat to minnows Zebre Parma in Round 2 of the URC.