Defeat against the Wallabies would condemn Wales to a record 11th successive Test match defeat.
Scrum-half Tomos Williams has been released from Wales’ Autumn Nations Series squad due to a shoulder injury.
The Welsh were beaten 19-24 last Sunday at Principality Stadium by Fiji and they will go in against the Wallabies with two alterations to the starting backs and two more up front.
Cardiff lock Teddy Williams has been called into Wales' squad to replace Ben Carter, who has been released after suffering a knee injury in training.
The four Welsh regions will all play each other over the next three weeks as part of the Pro14's traditional Christmas derby window.
Williams, 26, has made 35 appearances for the Welsh side since joining from Bristol Bears in 2018.
The Blues scrum-half is rather tongue-tied when it comes to talking about himself but Richie Rees believes he is someone who will be thrilling Welsh crowds for years to come.
Dragons have confirmed the signing of scrum-half Rhodri Williams from Bristol Rugby.