Wales have not won a Test match since the 2023 World Cup.
Warren Gatland is shy of quality in some areas but the Wales coach's Six Nations picks must deliver if he is to keep his job.
Both Gloucester backs failed to make the 34-strong group announced by Wales head coach Warren Gatland on Monday for a campaign that kicks off against France in Paris on January 31.
Edwards and Scarlets wing Ellis Mee are the Test rookies among a 34-strong group.
Gloucester coasted to a 31-7 European Challenge Cup victory over Scarlets at Kingsholm.
Blair Murray marked his return with a brace of tries as Scarlets secured a 32-15 bonus-point win over Dragons in Llanelli in the United Rugby Championship.
Wales slumped to a 12th successive Test match defeat and head coach Warren Gatland saw the pressure ramped up on him as world champions South Africa won 45-12 at the Principality Stadium.
Warren Gatland's men lost their twelfth Test of 2024 as they were thumped by the World Champion Springboks
No one is expecting Wales to beat South Africa but the performance will go a long way to proving Gatland retains the faith of his players
Speculation continues to rage about Gatland’s future after a record run of 11 successive Test match defeats.