Warren Gatland has named former New Zealand Schools wing Blair Murray in his 35-man squad for the Autumn Nations Series.
Gloucester fly-half Adam Hastings is set to make his return from injury on Friday against the Ospreys in the Challenge Cup quarter-final at Kingsholm.
Ospreys kept alive their hopes of an end of season play-off spot with an impressive 36-21 bonus-point win over Emirates Lions in Swansea.
Wales co-captain Dewi Lake is set to switch from his usual position of hooker to openside flanker for the first time since age-grade rugby to help his injury-hit Ospreys side.
The first Guinness Six Nations after a World Cup often sees a changing of the guard, with new faces emerging as a fresh four-year cycle begins.
The Sharks and the Ospreys meet in a historic match at the Twickenham Stoop on Friday night, as it will be the first time a United Rugby Championship match has ever taken place in England.
James Lowe was back with a bang as his electric 56th-minute try lit up Leinster’s 29-7 United Rugby Championship win over the Ospreys at the RDS.