There are seven changes to the starting XV, including two new caps in the pack, while there is also a first start for Sam Prendergast.
Beaten by New Zealand in their opening November match, the Irish got their Autumn Nations Series back on track with a 22-19 success versus the Pumas and they have now altered five backs and two forwards for the Aviva Stadium arrival of the Pacific Islanders.
A perennial problem for Irish rugby is once again rearing its ugly head.
Ulster head coach Richie Murphy has named his team for the BKT United Rugby Championship Round 6 match against Cardiff on Saturday - with no sign of hooker Rob Herring in the squad.
Ulster line-up doesn't bode well for Ireland's burgeoning injury crisis.
South Africa loosehead prop Steven Kitshoff has played his last game for Ulster, after the United Rugby Championship club confirmed he picked up a season-ending knee injury against ASM Clermont Auvergne in the Challenge Cup.
Stephen Ferris has expressed disappointment over Steven Kitshoff's performance at Ulster after an underwhelming six months with the Irish province.
Andy Farrell sat very prettily last Sunday in the Aviva Stadium media auditorium having just watched his Ireland team go two wins from two in the opening rounds of their Guinness Six Nations title defence.
Ulster will be boosted on Friday by the return of some of their World Cup players for their clash against United Rugby Championship winners Munster at the Kingspan Stadium.