Ireland have confirmed that Tadhg Furlong, Garry Ringrose and Mack Hansen are set to return for their final match of the Guinness Six Nations against Italy in Rome on Saturday.
Ireland will be without tighthead prop Tom O'Toole for their Guinness Six Nations opener against England next month after he was handed a six-week ban following his red card against Munster on December 20.
There are seven changes to the starting XV, including two new caps in the pack, while there is also a first start for Sam Prendergast.
Beaten by New Zealand in their opening November match, the Irish got their Autumn Nations Series back on track with a 22-19 success versus the Pumas and they have now altered five backs and two forwards for the Aviva Stadium arrival of the Pacific Islanders.
A perennial problem for Irish rugby is once again rearing its ugly head.
Ulster head coach Richie Murphy has named his team for the BKT United Rugby Championship Round 6 match against Cardiff on Saturday - with no sign of hooker Rob Herring in the squad.
Ulster line-up doesn't bode well for Ireland's burgeoning injury crisis.
South Africa loosehead prop Steven Kitshoff has played his last game for Ulster, after the United Rugby Championship club confirmed he picked up a season-ending knee injury against ASM Clermont Auvergne in the Challenge Cup.
Stephen Ferris has expressed disappointment over Steven Kitshoff's performance at Ulster after an underwhelming six months with the Irish province.